2044276-16-4

2044276-16-4 structure

Name: Glycolithocholic Acid-d4 MaxSpec® Standard
Chemical Name: Glycolithocholic Acid-d4 MaxSpec® Standard
CAS Number: 2044276-16-4
Molecular Formula: C₂₆H₃₉D₄NO₄
Molecular Weight: 437.649
Catalog: Research Areas Inflammation/Immunology
Create Date: 2021-07-21 17:59:46
Modify Date: 2024-01-09 09:52:36
Glycolithocholic acid-d4 is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].

Name	Glycolithocholic Acid-d4 MaxSpec® Standard
Synonyms	MFCD06658889 Glycine, N-[(3α,5β)-3-hydroxy-24-oxocholan-24-yl-2,2,4,4-d4]- N-[(3α,5β)-3-Hydroxy-24-oxo(2,2,4,4-2H4)cholan-24-yl]glycine Glycolithocholic Acid-d4

Description	Glycolithocholic acid-d4 is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].
References	[1]. Tanno N, et, al. Biliary lipid composition in heterozygous familial hypercholesterolemia and influence of treatment with probucol. Dig Dis Sci. 1994 Jul;39(7):1586-91. [2]. Ang ZH, et, al. Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis. World J Gastroenterol. 2021 Jun 28;27(24):3609-3629. [3]. Bansal S, et, al. Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites. J Pharmacol Exp Ther. 2019 Jun;369(3):389-405. [4]. Sanyal AJ, et, al. Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases. JHEP Rep. 2021 Feb 19;3(3):100255.

Density	1.1±0.1 g/cm3
Boiling Point	619.7±30.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₉D₄NO₄
Molecular Weight	437.649
Flash Point	328.6±24.6 °C
Exact Mass	437.344330
LogP	5.58
Vapour Pressure	0.0±4.1 mmHg at 25°C
Index of Refraction	1.533

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