2421118-05-8

2421118-05-8 structure

Name: JKE-1716
Chemical Name: JKE-1716
CAS Number: 2421118-05-8
Molecular Formula: C₂₀H₂₀Cl₂N₄O₄
Molecular Weight: 451.303
Catalog: Signaling Pathways Apoptosis Ferroptosis
Create Date: 2021-08-15 09:39:40
Modify Date: 2024-01-17 23:42:09
JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition[1].

Name	JKE-1716
Synonyms	(3Z)-1-{4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}-3-(hydroxyimino)-3-nitro-1-propanone 1,3-Propanedione, 1-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-3-nitro-, 3-oxime, (3Z)- JKE-1716

Description	JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Apoptosis >> Ferroptosis
Target	GPX4[1]; Ferroptosis[1]
In Vitro	JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability[1]. JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4[1]. Cell Viability Assay[1] Cell Line: LOX-IMVI cells Concentration: 0~100 nΜ Incubation Time: 72 hours Result: Inhibited cell viability.
References	[1]. Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020;16(5):497-506.