Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ara-F-NAD+
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Ara-F-NAD+
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

133575-27-6

133575-27-6 structure

133575-27-6 structure

Name: Ara-F-NAD+
Chemical Name: Ara-F-NAD+
CAS Number: 133575-27-6
Molecular Formula: C₂₁H₂₆FN₇O₁₃P₂
Molecular Weight: 665.42
Catalog: Research Areas Neurological Disease
Create Date: 2021-09-11 12:32:49
Modify Date: 2024-01-09 00:33:22
Ara-F-NAD+, an arabino analogue of NAD+, is a potent, slow-binding CD38 NADase inhibitor, with a Ki of 169 nM[1][2].

Name	Ara-F-NAD+

Description	Ara-F-NAD+, an arabino analogue of NAD+, is a potent, slow-binding CD38 NADase inhibitor, with a Ki of 169 nM[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	The leucoyte surface antigen CD38 has been shown to be an ecto-enzyme with multiple catalytic activities. It is principally a NAD+ glycohydrolase that transforms NAD+ into ADP-ribose and nicotinamide. CD38 is also able to produce small amounts of cyclic ADP-ribose (ADP-ribosyl cyclase activity) and to hydrolyse this cyclic metabolite into ADP-ribose (cyclic ADP-ribose hydrolase activity)[1].
References	[1]. Berthelier V, et al. Human CD38 is an authentic NAD(P)+ glycohydrolase. Biochem J. 1998;330 ( Pt 3)(Pt 3):1383-1390. doi:10.1042/bj3301383 [2]. Wang S, et al. Design, synthesis and SAR studies of NAD analogues as potent inhibitors towards CD38 NADase. Molecules. 2014;19(10):15754-15767. Published 2014 Sep 29.

Molecular Formula	C₂₁H₂₆FN₇O₁₃P₂
Molecular Weight	665.42