1380782-27-3

1380782-27-3 structure

Name: T2AA
Chemical Name: 4-{4-[(2S)-2-Amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol
CAS Number: 1380782-27-3
Molecular Formula: C₁₅H₁₅I₂NO₃
Molecular Weight: 511.093
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2021-09-15 16:22:04
Modify Date: 2024-04-06 18:23:58
T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1].

Name	4-{4-[(2S)-2-Amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol
Synonyms	4-{4-[(2S)-2-Amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol Benzenepropanol, β-amino-4-(4-hydroxyphenoxy)-3,5-diiodo-, (βS)-

Description	T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	T2AA(15 μM, 72 h) 抑制链间 DNA 交联（ICL）修复，它可以阻止作为 ICL 修复中间体形成的 DNA 双链断裂（DSB）的分解，具有抑制 DSB 修复的能力[1]。
References	[1]. Akira Inoue, et al. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem. 2014 Mar 7;289(10):7109-7120.