2341740-84-7
2341740-84-7 structure
- Name: BI-3663
- Chemical Name: BI-3663
- CAS Number: 2341740-84-7
- Molecular Formula: C44H42F3N7O12
- Molecular Weight: 917.839
- Create Date: 2021-09-09 20:54:22
- Modify Date: 2024-01-20 11:46:50
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BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-446
| Name | BI-3663 |
|---|---|
| Synonyms |
5,8,11-Trioxa-2-azatetradecan-14-amide, 1-[4-[[4-[(2,3-dihydro-3-oxo-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-3-methoxyphenyl]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-oxo-
N-[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-1-[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl}amino)phenyl]-1-oxo-5,8,11-trioxa-2-azatetradecan-14-amide |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C44H42F3N7O12 |
| Molecular Weight | 917.839 |
| Exact Mass | 917.284363 |
| LogP | 2.31 |
| Index of Refraction | 1.627 |