86770-69-6
86770-69-6 structure
- Name: Azido-PEG6-alcohol
- Chemical Name: 2[-2-(2-{2-[2-(2-hydroxyethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]- ethyl azide
- CAS Number: 86770-69-6
- Molecular Formula: C12H25N3O6
- Molecular Weight: 307.34300
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2016-08-08 16:48:39
- Modify Date: 2024-01-03 16:48:20
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Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
| Name | 2[-2-(2-{2-[2-(2-hydroxyethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]- ethyl azide |
|---|---|
| Synonyms |
17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol
2-[2-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethanol 3,6,9,12,15-pentaoxa-17-azidoheptadecan-1-ol 17-azido-3,6,9,12,15-pentaoxa-1-heptadecanol 23-azido-3,6,9,12,15,-heptaoxatricosan-1-ol 17-azido-3,6,9,12,15-pentaoxaheptadecanol |
| Description | Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
| Molecular Formula | C12H25N3O6 |
|---|---|
| Molecular Weight | 307.34300 |
| Exact Mass | 307.17400 |
| PSA | 116.13000 |
| Storage condition | -20°C |
| Precursor 0 | |
|---|---|
| DownStream 2 | |
