27686-84-6

27686-84-6 structure

Name: Masoprocol
Chemical Name: Masoprocol
CAS Number: 27686-84-6
Molecular Formula: C₁₈H₂₂O₄
Molecular Weight: 302.36500
Catalog: Chemical reagent Organic reagent Phenols
Create Date: 2018-06-11 17:09:24
Modify Date: 2024-01-10 16:50:42
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes[1][2][3].

Name	Masoprocol
Synonyms	norhydroguaiareticacid chx-100

Description	Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes[1][2][3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Metabolic Disease
In Vitro	Masoprocol (30 µM; 90 min) shows high basal and insulin-stimulated glucose clearance in adipocytes[2].
In Vivo	Masoprocol (150 mg/kg; i.g.; twice a day for 12 days) shows antihyperglycemic activity with the decreases in glucose concentration in plasma in male C57BL/ks-db/db mice[1]. Masoprocol （0.83 mmol/kg; twice a day for 4 days）shows low glucose concentrations an average of 35% and low triglyceride concentrations of 80% compared with the vehicle at a rat model of type II diabetes[2].Masoprocol (40-80 mg/kg; p.o.; twice daily for 8 days) significantly reduces hepatic triglyceride (TG) secretion (P<.01) and liver TG content in a nondiabetic rat model with dietary-induced hypertriglyceridemia(HTG)[3].
References	[1]. Luo J, et al. Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata). Eur J Pharmacol. 1998 Apr 3;346(1):77-9. [2]. Reed MJ, et al. Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes. Diabetologia. 1999 Jan;42(1):102-6. [3]. Scribner KA, et al. Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Metabolism. 2000 Sep;49(9):1106-10.

Density	1.241 g/cm3
Boiling Point	526.5ºC at 760 mmHg
Melting Point	185.5ºC
Molecular Formula	C₁₈H₂₂O₄
Molecular Weight	302.36500
Flash Point	247.8ºC
Exact Mass	302.15200
PSA	80.92000
LogP	3.56640
Vapour Pressure	1.06E-11mmHg at 25°C
Index of Refraction	1.626

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