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66852-54-8

66852-54-8 structure
66852-54-8 structure

Name Halobetasol propionate
Synonyms (6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(chloroacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propanoate
halobetasolpropionate
halobetasol 17-propionate
(6a,11b,16b)-21-Chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
21-Chloro-6α,9-difluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate
Ultravate
Uiobetasol Propionate
Pregna-1,4-diene-3,20-dione, 21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (6α,11β,16β)-
Miracorten
Halobetasol
ulobetasol propionate
propanoate de (6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(chloroacétyl)-6,9-difluoro-11-hydroxy-10,13,16-triméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yle
(6α,11β,16β)-21-chloro-6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(Chloracetyl)-6,9-difluor-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-ylpropanoat
MFCD00866013
21-Chloro-6a,9-difluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-Propionate
(6α,11β,16β)-21-Chloro-6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propionate
Halobetasol (propionate)
Description Halobetasol propionate is a synthetic corticosteroid for topical dermatological use; exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties.
Related Catalog
Density 0.934 g/mL at 25 °C(lit.)
Boiling Point 55 °C0.3 mm Hg(lit.)
Melting Point -32°C
Molecular Formula C25H31ClF2O5
Molecular Weight 484.96000
Flash Point 185 °F
Exact Mass 484.18300
PSA 80.67000
LogP 4.05110
Index of Refraction n20/D 1.539(lit.)
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3723500
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxo propoxy)-, (6-alpha,11-beta,16-beta)-
CAS REGISTRY NUMBER :
66852-54-8
LAST UPDATED :
199409
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C25-H31-Cl-F2-O5
MOLECULAR WEIGHT :
485.01

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>15 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 27,304,1991
Hazard Codes T
Risk Phrases R22:Harmful if swallowed. R23:Toxic by inhalation. R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36-S45-S7/9
RIDADR 2810
WGK Germany 3
RTECS BY4190000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2937229000
HS Code 2937229000