382-67-2
382-67-2 structure
- Name: Desoximetasone
- Chemical Name: desoximetasone
- CAS Number: 382-67-2
- Molecular Formula: C22H29FO4
- Molecular Weight: 376.462
- Catalog: analytical chemistry Standard Forensic and veterinary standards
- Create Date: 2018-02-14 08:00:00
- Modify Date: 2024-01-03 19:34:16
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Desoximetasone(Topicort) is a medication belonging to the family of medications known as topical corticosteroids; is used for the relief of various skin conditions, including rashes.IC50 value:Target: When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of desoximetasone over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.[1] Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes.
| Name | desoximetasone |
|---|---|
| Synonyms |
desoximetasonum [INN_la]
Desoximetasone EINECS 206-845-3 9-Fluoro-11-β,21-dihydroxy-16-α-methylpregna-1,4-diene-3,20-dione MFCD00083301 desoximetasona [INN_es] (11β,16α)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11β,16α)- desoximetasone [INN_en] Desoxymetasone |
| Description | Desoximetasone(Topicort) is a medication belonging to the family of medications known as topical corticosteroids; is used for the relief of various skin conditions, including rashes.IC50 value:Target: When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of desoximetasone over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.[1] Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 532.3±50.0 °C at 760 mmHg |
| Melting Point | 217ºC |
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 376.462 |
| Flash Point | 275.7±30.1 °C |
| Exact Mass | 376.204987 |
| PSA | 74.60000 |
| LogP | 2.20 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.574 |
| Storage condition | Refrigerator |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H315-H317-H319-H332-H335-H351 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R20/21/22;R36/37/38;R40;R43 |
| Safety Phrases | S22-S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TU3834000 |
| HS Code | 2914700090 |
|
~83%
382-67-2 |
| Literature: TARO PHARMACEUTICAL INDUSTRIES LTD.; CHERNIAK, Simon; CYJON, Rosa; OZER, Ilana; NUDELMAN, Igor Patent: WO2012/11106 A1, 2012 ; Location in patent: Page/Page column 15-16 ; |
| Precursor 1 | |
|---|---|
| DownStream 1 | |
![(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylic acid structure](https://image.chemsrc.com/caspic/067/75262-69-0.png)
| HS Code | 2914700090 |
|---|---|
| Summary | HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |