74513-62-5

74513-62-5 structure

Name: Trimegestone
Chemical Name: Trimegestone
CAS Number: 74513-62-5
Molecular Formula: C₂₂H₃₀O₃
Molecular Weight: 342.47
Catalog: API Hormone and endocrine-regulating drugs Estrogen and progestogen drugs
Create Date: 2018-05-13 08:00:00
Modify Date: 2024-01-03 07:52:14
Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes[1][2].

Name	Trimegestone
Synonyms	(8S,13S,14S,17S)-17-[(2S)-2-Hydroxypropanoyl]-13,17-dimethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one 17β-(S)-Lactoyl-17-methylestra-4,9-dien-3-one (8S,13S,14S,17S)-17-[(2S)-2-Hydroxypropanoyl]-13,17-dimethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name) Trimegestone trimebutinemaleate Estra-4,9-dien-3-one, 17-[(2S)-2-hydroxy-1-oxopropyl]-17-methyl-, (17β)-

Description	Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes[1][2].
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Endocrinology Signaling Pathways >> Others >> Androgen Receptor
References	[1]. Wahab M, et al. Trimegestone: expanding therapeutic choices for the treatment of the menopause. Expert Opin Investig Drugs. 2001 Sep;10(9):1737-44. [2]. Zhang Z, et al. In vitro characterization of trimegestone: a new potent and selective progestin. Steroids. 2000 Oct-Nov;65(10-11):637-43.