33889-69-9

33889-69-9 structure

Name: Silicristin
Chemical Name: silychristin
CAS Number: 33889-69-9
Molecular Formula: C₂₅H₂₂O₁₀
Molecular Weight: 482.436
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-06-03 08:00:00
Modify Date: 2024-01-02 20:13:29
Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2].

Name	silychristin
Synonyms	Silicristin EINECS 251-720-9 Silicristinum (2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydrochromen-4-one Silicristinum [INN-Latin] Silicristina (2R,3R)-3,5,7-Trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydro-4H-chromen-4-one Silicristina [INN-Spanish] 4H-1-Benzopyran-4-one, 2-[(2R,3S)-2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- Silychristin Silymarin II Silicristine [INN-French] (2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-2,3-dihydrobenzofuran-5-yl]chroman-4-one Silicristine

Description	Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
References	[1]. Biedermann D, et al. Silychristin: Skeletal Alterations and Biological Activities. J Nat Prod. 2016 Dec 23;79(12):3086-3092. [2]. Johannes J, et al. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Endocrinology. 2016 Apr;157(4):1694-701.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	22-45
RIDADR	NONH for all modes of transport

Precursor 3
1835-11-6 124662-51-7 16414-34-9
DownStream 0