Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Morroniside
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Morroniside
Price: ￥Inquiry/5mg
Purity: 98.0%
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Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Morroniside
Price: ￥938.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Morroniside
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Morroniside
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

25406-64-8

25406-64-8 structure

25406-64-8 structure

Name: Morroniside
Chemical Name: methyl 3-hydroxy-1-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,4a,8,8a-hexahydropyrano[3,4-c]pyran-5-carboxylate
CAS Number: 25406-64-8
Molecular Formula: C₁₇H₂₆O₁₁
Molecular Weight: 406.382
Catalog: Biochemical Plant extracts
Create Date: 2018-04-27 08:00:00
Modify Date: 2024-01-02 17:44:25
Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

Name	methyl 3-hydroxy-1-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,4a,8,8a-hexahydropyrano[3,4-c]pyran-5-carboxylate
Synonyms	N1489 1H,3H-Pyrano[3,4-c]pyran-5-carboxylic acid, 8-(β-D-glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-, methyl ester, (1S,4aS,8S,8aS)- Morroniside Methyl (1S,3R,4aS,8S,8aS)-8-(β-D-glucopyranosyloxy)-3-hydroxy-1-methyl-4,4a,8,8a-tetrahydro-1H,3H-pyrano[3,4-c]pyran-5-carboxylate Methyl (1S,4aS,8S,8aS)-8-(β-D-glucopyranosyloxy)-3-hydroxy-1-methyl-4,4a,8,8a-tetrahydro-1H,3H-pyrano[3,4-c]pyran-5-carboxylate b-Morroniside 1H,3H-Pyrano[3,4-c]pyran-5-carboxylic acid, 8-(β-D-glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-, methyl ester, (1S,3R,4aS,8S,8aS)- Morronisid Morroniside (α+β)

Description	Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
Related Catalog	Natural Products >> Terpenoids and Glycosides Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	MMP2 MMP9
In Vivo	Morroniside reduces the expression of MMP2 and MMP9 in an I/R injury model. Treatment with Morroniside significantly reduces I/R‑associated neuron apoptosis in a dose dependent manner. The results demonstrate that active caspase‑3 and Bax are significantly upregulated in the model group compared with the control group, while Bcl‑2 is significantly downregulated. The expression of active caspase‑3 and Bax is significantly downregulated by Morroniside treatment in a dose‑dependent manner, while the expression of Bcl‑2 is significantly upregulated[1]. Morroniside has an ameliorative effect on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice[2].
Animal Admin	Rats[1] A total of 50 adult male Sprague Dawley rats (age, 7 8 weeks; weight, 260 280 g) are used. Rats are randomly assigned into five groups (n=10 in each). Rats in the control group undergo sham surgery. All other rats undergo suture occluded surgery, with a 0.26 mm nylon monofilament inserted through the right common carotid artery and are divided into groups as follows: The cerebral I/R injury model group (model), no treatment; low dose group, 30 mg/kg/day Morroniside by gavage; moderate dose group, 90 mg/kg/day Morroniside by gavage; high dose group, 270 mg/kg/day Morroniside by gavage. Rats in the control and model groups receive an equal volume of normal saline[1].
References	[1]. Zeng G, et al. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 2018 Sep;16(3):2229-2234. [2]. Park CH, et al. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol Pharm Bull. 2011;34(10):1559-65.

Density	1.5±0.1 g/cm3
Boiling Point	635.6±55.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₆O₁₁
Molecular Weight	406.382
Flash Point	227.0±25.0 °C
Exact Mass	406.147522
PSA	164.37000
LogP	-3.16
Vapour Pressure	0.0±4.2 mmHg at 25°C
Index of Refraction	1.597
Storage condition	2-8C