Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Serotonin hydrochloride
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Serotonin hydrochloride
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Serotonin hydrochloride(5-HT)
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Serotonin hydrochloride(5-HT)
Price: $100.0/100mg $200.0/250mg $400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

153-98-0

153-98-0 structure

Name: Serotonin hydrochloride
Chemical Name: Serotonin hydrochloride
CAS Number: 153-98-0
Molecular Formula: C₁₀H₁₃ClN₂O
Molecular Weight: 212.676
Catalog: Biochemical Amino acids and their derivatives Amino alcohol derivative
Create Date: 2018-02-21 08:00:00
Modify Date: 2024-01-02 12:54:27
Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

Name	Serotonin hydrochloride
Synonyms	3-(2-aminoethyl)-1H-indol-5-ol,hydrochloride 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride,5-HT,5-Hydroxytryptamine hydrochloride 5-hydroxytryptamine hydrochloride Serotonin HCl 1H-Indol-5-ol, 3-(2-aminoethyl)-, hydrochloride (1:1) 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride (1:1) EINECS 244-464-4 MFCD00012686 5-Hydroxytryptamine HCl

Description	Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> COMT Signaling Pathways >> Neuronal Signaling >> COMT Research Areas >> Neurological Disease
Target	5-HT receptor[1] Ki: 44 μM (COMT)[1]
In Vitro	Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki= 44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT[1].
In Vivo	Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001)[1]. A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis[2].
Cell Assay	For macrophage culture, peritoneal cavity cells are collected from WT and IL-13-/- mice with or without dextran sodium sulfate (DSS) treatment and cultured. Cells are plated at a concentration of 3.0×106 cells per millilitre, and treated with either lipopolysaccharides (LPS); (100 ng/mL) or Serotonin hydrochloride (10-10 M) for 24 hours. The culture supernatant are collected and stored in -80°C until determination of cytokine levels using protein array system[2].
Animal Admin	Dextran sodium sulfate (DSS) colitis is induced by orally administering 5% DSS in drinking water for 5 days. In a separate experiment, IL-13-/- mice are injected subcutaneously with 100 mg/kg of Serotonin hydrochloride (5-HTP) twice daily for 8 days beginning 3 days prior to induction of DSS colitis; whereas, the control IL-13-/- mice receive saline as vehicle. Animals are anaesthetized prior to euthanization via cervical dislocation at the conclusion of each experiment or if they reach a predetermined end point (ie, loss of ≥20% body weight and/or significant deterioration of body condition)[2].
References	[1]. Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25. [2]. Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28;8(8):e72774.

Boiling Point	416.1ºC at 760 mmHg
Melting Point	149-154 °C(lit.)
Molecular Formula	C₁₀H₁₃ClN₂O
Molecular Weight	212.676
Flash Point	205.4ºC
Exact Mass	212.071640
PSA	62.04000
LogP	2.87700
Vapour Pressure	1.63E-07mmHg at 25°C
Storage condition	2-8°C
Stability	Stable, but light sensitive and hygroscopic. Incompatible with strong oxidizing agents.
Water Solubility	soluble

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S22-S26-S36
RIDADR	UN2811
WGK Germany	3
RTECS	NM2571000
Packaging Group	III
Hazard Class	6.1
HS Code	2933990090

Precursor 0
DownStream 10
108560-71-0 608-07-1 487-93-4 1892-21-3
3000-36-0 374680-35-0 20776-45-8 73-31-4
53157-50-9 52055-23-9

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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