Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Methyl gallate
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Methyl gallate
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Methyl gallate
Price: ￥308.0/500g ￥98.0/100g ￥68.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Methyl gallate
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Methyl gallate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

99-24-1

99-24-1 structure

99-24-1 structure

Name: Methyl gallate
Chemical Name: Methyl Gallate
CAS Number: 99-24-1
Molecular Formula: C₈H₈O₅
Molecular Weight: 184.146
Catalog: Chemical reagent Organic reagent Ester Methyl ester compound
Create Date: 2018-04-18 08:00:00
Modify Date: 2024-01-02 21:13:17
Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity.

Name	Methyl Gallate
Synonyms	Methyl gallate MFCD00002194 3,4,5-Trihydroxybenzoic acid methyl ester Benzoic acid, 3,4,5-trihydroxy-, methyl ester Methyl 3,4,5-trihydroxybenzoate EINECS 202-741-7

Description	Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Cardiovascular Disease Research Areas >> Cancer Research Areas >> Infection Natural Products >> Phenols
Target	Bacterial[1]
In Vitro	The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL)[1]. Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H2O2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H2O2 (8.0 mM) for a 3 h period[2]. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate[3].
Cell Assay	KB cells, a human mouth epithelial cell line, are treated with Methyl gallate (1-8 mg/mL) for 24 h. Cytotoxicity of Methyl gallate is assessed by a modified MTT assay[1].
References	[1]. Kang MS, et al. Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol. 2008 Dec;46(6):744-50. [2]. Hsieh TJ, et al. Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells. Food Chem Toxicol. 2004 May;42(5):843-50. [3]. Lee H, et al. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. J Immunol. 2010 Dec 1;185(11):6698-705.

Density	1.5±0.1 g/cm3
Boiling Point	450.1±40.0 °C at 760 mmHg
Melting Point	201-204 °C
Molecular Formula	C₈H₈O₅
Molecular Weight	184.146
Flash Point	190.8±20.8 °C
Exact Mass	184.037170
PSA	86.99000
LogP	1.54
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.631
Storage condition	2-8°C
Water Solubility	SOLUBLE IN HOT WATER

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LW8000000

CHEMICAL NAME :: Gallic acid, methyl ester

CAS REGISTRY NUMBER :: 99-24-1

BEILSTEIN REFERENCE NO. :: 2113180

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H8-O5

MOLECULAR WEIGHT :: 184.16

WISWESSER LINE NOTATION :: QVR CQ DQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 784 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H317-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R22;R36/37/38;R43
Safety Phrases	S26-S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LW8000000
HS Code	2918290000

Precursor 9
67-56-1 149-91-7 77-78-1 66656-94-8
75-36-5 74-88-4 35388-10-4 7647-01-0
7664-93-9
DownStream 10
111394-44-6 3934-84-7 3934-86-9 41303-74-6
146300-69-8 143259-87-4 1486-47-1 142531-43-9
477-90-7 188685-16-7

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%