151057-13-5

151057-13-5 structure

Name: L-701252
Chemical Name: 7-chloro-3-(cyclopropanecarbonyl)-4-hydroxy-1H-quinolin-2-one
CAS Number: 151057-13-5
Molecular Formula: C₁₃H₁₀ClNO₃
Molecular Weight: 263.67600
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-12-05 13:35:32
Modify Date: 2024-01-04 21:44:11
L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1].

Name	7-chloro-3-(cyclopropanecarbonyl)-4-hydroxy-1H-quinolin-2-one
Synonyms	L-701,252 Tocris-0705

Description	L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	NMDA receptor[1]
In Vivo	L-701252 (50 mg/kg; i.p.) provides a small non-significant protection[1]. Animal Model: 3-Months Male Mongolian gerbils (60 g)[1] Dosage: 50 mg/kg Administration: i.p. Result: Provided a small non-significant protection.
References	[1]. Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154. [2]. Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242.

Precursor 2
60064-34-8 139422-18-7
DownStream 0