136181-87-8

136181-87-8 structure

Name: N-Palmitoyl Dopamine
Chemical Name: N-[2-(3,4-dihydroxyphenyl)ethyl]hexadecanamide
CAS Number: 136181-87-8
Molecular Formula: C₂₄H₄₁NO₃
Molecular Weight: 391.587
Create Date: 2016-05-31 22:00:11
Modify Date: 2024-01-11 09:45:50
N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide[1].

Name	N-[2-(3,4-dihydroxyphenyl)ethyl]hexadecanamide
Synonyms	Palmitoyl dopamine HMS3268B22 N-[2-(3,4-Dihydroxyphenyl)ethyl]hexadecanamide Hexadecanamide, N-[2-(3,4-dihydroxyphenyl)ethyl]- BML3-G01 N-Palmitoyl Dopamine PALDA

Description	N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	PALDA (0.1-10 μM), the EC50 of N-arachidonoyl-dopamine (NADA) is lowered from approximately 90 to approximately 30 nM. The effect on intracellular Ca2+ by another endovanilloid, N-arachidonoyl-ethanolamine (anandamide, 50 nM), is also enhanced dose-dependently by PALDA. PALDA also acted in synergy with low pH (6.0-6.7) to enhance intracellular Ca2+ via TRPV1[1].
References	[1]. Luciano De Petrocellis, et al. Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br J Pharmacol. 2004 Sep;143(2):251-6.