Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Bupranolol
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Bupranolol
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

14556-46-8

14556-46-8 structure

14556-46-8 structure

Name: Bupranolol
Chemical Name: Bupranolol
CAS Number: 14556-46-8
Molecular Formula: C₁₄H₂₂ClNO₂
Molecular Weight: 271.78300
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-03-06 08:00:00
Modify Date: 2024-01-06 10:57:46
Bupranolol is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity[1].

Name	Bupranolol
Synonyms	Ophtorenin Bupranol

Description	Bupranolol is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
Target	β-adrenoceptor
In Vitro	Bupranolol (1~3 μM) shifts isoprenaline-induced relaxation in the presence of 30 μM propranolol. Bupranolol acts as a competitive antagonist of isoprenaline-induced relaxation in the presence of 300 nM propranolol, with a pA2 value of 5.90. Bupranolol antagonizes β1- and β2-ARs with pA2 values of ≈9.0, and also antagonizes β3-AR with a pA2 value of 6.0[1].
References	[1]. Chino D, et al. Pharmacological identification of β-adrenoceptor subtypes mediating isoprenaline-induced relaxation of guinea pig colonic longitudinal smooth muscle. J Smooth Muscle Res. 2018;54(0):13-27. [2]. Babu RJ, et al. Effect of cyclodextrins on the complexation and transdermal delivery of bupranolol through rat skin. Int J Pharm. 2004;271(1-2):155-165.

Density	1.098g/cm3
Boiling Point	396.3ºC at 760mmHg
Molecular Formula	C₁₄H₂₂ClNO₂
Molecular Weight	271.78300
Flash Point	193.5ºC
Exact Mass	271.13400
PSA	41.49000
LogP	3.16710
Vapour Pressure	5.44E-07mmHg at 25°C
Index of Refraction	1.522

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA8430000

CHEMICAL NAME :: 2-Propanol, 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)-

CAS REGISTRY NUMBER :: 14556-46-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H22-Cl-N-O2

MOLECULAR WEIGHT :: 271.82

WISWESSER LINE NOTATION :: 1X1&1&M1YQ1OR BG E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1022,1977

HS Code	2922509090

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%