97845-62-0

97845-62-0 structure

Name: Penciclovir Sodium
Chemical Name: sodium,4-(2-amino-6-oxo-3H-purin-9-yl)-2-(hydroxymethyl)butan-1-olate
CAS Number: 97845-62-0
Molecular Formula: C₁₀H₁₄N₅NaO₃
Molecular Weight: 275.24000
Catalog: Signaling Pathways Anti-infection HSV
Create Date: 2016-12-26 01:58:43
Modify Date: 2024-04-05 09:21:28
Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse[1][2].

Name	sodium,4-(2-amino-6-oxo-3H-purin-9-yl)-2-(hydroxymethyl)butan-1-olate
Synonyms	9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine monosodium salt 2-Amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one monosodium salt Penciclovir cream Penciclovir sodium [USAN] Penciclovir sodium 1,9-Dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one monosodium salt

Description	Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection
Target	HSV-1:0.5 μg/mL (EC50) HSV-2:0.8 μg/mL (EC50)
In Vitro	Penciclovir sodium (0-100 µg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively[1]. Penciclovir sodium (0-100 µg/ml) shows no-toxic to uninfected human cells[1]. Cell Cytotoxicity Assay[1] Cell Line: MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells Concentration: 0-100 µg/ml Incubation Time: Result: Showed no-toxic with IC50s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5,WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13,Primary cells, respectively.
In Vivo	Penciclovir sodium (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse[2]. Animal Model: Three-week-old female Balb/c mice[2] Dosage: 100 mg/kg Administration: S.c.; daily for 5 days Result: Reduced virus titres in the respiratory organs of both w/t- and PR3-infected mice.
References	[1]. M.R. Boyd, et al. Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern. Antiviral Chemistry and Chemotherapy, 1993, (1): 3-11. [2]. de la Fuente R, et al. The acyclic nucleoside analogue penciclovir is a potent inhibitor of equine herpesvirus type 1 (EHV-1) in tissue culture and in a murine model. Antiviral Res. 1992 May;18(1):77-89.

Molecular Formula	C₁₀H₁₄N₅NaO₃
Molecular Weight	275.24000
Exact Mass	275.09900
PSA	132.88000

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0791566

CHEMICAL NAME :: 6H-Purin-6-one, 1,9-dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)but yl)-, monosodium salt

CAS REGISTRY NUMBER :: 97845-62-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H14-N5-O3.Na

MOLECULAR WEIGHT :: 275.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 640 umol/kg/24H (Intermittent)

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 369,65,1996

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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