2247534-79-6
2247534-79-6 structure
- Name: L-AP4 monohydrate
- Chemical Name: L-AP4 monohydrate
- CAS Number: 2247534-79-6
- Molecular Formula: C4H12NO6P
- Molecular Weight: 201.11
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2021-09-15 13:41:11
- Modify Date: 2024-01-10 18:37:43
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L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].
| Name | L-AP4 monohydrate |
|---|
| Description | L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2]. |
|---|---|
| Related Catalog | |
| Target |
mGlu4:0.13 μM (EC50) mGlu8:0.29 μM (EC50) mGlu6:1.0 μM (EC50) mGlu7:249 μM (EC50) |
| In Vivo | L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2]. Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2]. Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2]. Animal Model: Rats.[2] Dosage: 5-30 μg. Administration: Intrathecal inhection 4-5 days. Result: Dose-dependently increased paw withdrawal threshold. |
| References |
| Molecular Formula | C4H12NO6P |
|---|---|
| Molecular Weight | 201.11 |