1386980-55-7

1386980-55-7 structure

Name: DYRKs-IN-1 hydrochloride
Chemical Name: DYRKs-IN-1 hydrochloride
CAS Number: 1386980-55-7
Molecular Formula: C₃₀H₃₁Cl₂N₇O₄
Molecular Weight: 624.52
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK DYRK
Create Date: 2021-09-11 08:53:50
Modify Date: 2024-01-10 21:37:46
DYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity[1][2].

Name	DYRKs-IN-1 hydrochloride

Description	DYRKs-IN-1 hydrochloride is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. DYRKs-IN-1 hydrochloride has antitumor activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK
Target	DYRK1A:5 nM (IC50) DYRK1B:8 nM (IC50)
In Vitro	DYRKs-IN-1 hydrochloride (compound 30) increases the cellular potency against the human colon tumor cell line SW 620 with an EC50 of 27 nM[1]. DYRKs-IN-1 hydrochloride (Example 183) is a potent DYRKs inhibitor[2].
References	[1]. Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6610-5. [2]. Kevin Anderson, et al. Pyrido pyrimidines. US20120184542A1.

Molecular Formula	C₃₀H₃₁Cl₂N₇O₄
Molecular Weight	624.52