DC Chemicals Limited
China
Product Name: Modified MMAF
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

1352202-47-1

1352202-47-1 structure

1352202-47-1 structure

Name: Modified MMAF
Chemical Name: Modified MMAF
CAS Number: 1352202-47-1
Molecular Formula: C₄₅H₇₃N₇O₈
Molecular Weight: 840.10
Catalog: Research Areas Cancer
Create Date: 2021-09-11 16:38:29
Modify Date: 2024-01-12 10:52:46
Modified MMAF, an ADC cytotoxin, can be used in the synthesis of Antibody-drug Conjugate (ADC). Modified MMAF can be used for the targeted treatment of cancer[1].

Name	Modified MMAF

Description	Modified MMAF, an ADC cytotoxin, can be used in the synthesis of Antibody-drug Conjugate (ADC). Modified MMAF can be used for the targeted treatment of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay[2].
References	[1]. Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection [published correction appears in Cancer Res. 2010 Feb 1;70(3):1275. Slaga, Dion S [added]]. Cancer Res. 2009;69(6):2358-2364. [2]. Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006;17(1):114-124.

Molecular Formula	C₄₅H₇₃N₇O₈
Molecular Weight	840.10