2629314-68-5
2629314-68-5 structure
- Name: MRTX9768
- Chemical Name: MRTX9768
- CAS Number: 2629314-68-5
- Molecular Formula: C24H17FN6O
- Molecular Weight: 424.43
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2021-09-11 09:27:09
- Modify Date: 2024-01-09 19:08:20
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MRTX9768 is a potent, orally active PRMT5 inhibitor. MRTX9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors[1].
| Name | MRTX9768 |
|---|
| Description | MRTX9768 is a potent, orally active PRMT5 inhibitor. MRTX9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors[1]. |
|---|---|
| Related Catalog | |
| Target |
PRMT5[1] |
| In Vitro | MRTX9768 inhibits SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM)[1]. |
| In Vivo | In xenograft studies, oral administration of MRTX9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors[1]. |
| References |
| Molecular Formula | C24H17FN6O |
|---|---|
| Molecular Weight | 424.43 |