2377881-92-8
2377881-92-8 structure
- Name: MSA-2 dimer
- Chemical Name: MSA-2 dimer
- CAS Number: 2377881-92-8
- Molecular Formula: C29H28O8S2
- Molecular Weight: 568.66
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2021-09-09 19:49:57
- Modify Date: 2024-01-09 20:56:33
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MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide[1].
| Name | MSA-2 dimer |
|---|
| Description | MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide[1]. |
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| Related Catalog | |
| Target |
Kd: 145 μM (STING)[1] |
| In Vivo | MSA-2 dimer (60 mg/kg; p.o.; 50 days) inhibits tumor growth and prolongs overall survival[1]. MSA-2 dimer (40 mg/kg; s.c.; 25 days) induces complete tumor regression[1]. MSA-2 dimer (60 mg/kg; p.o.; 4 hours) increases proinflammatory cytokine (IFN-β) level in tumors[1]. MSA-2 dimer (60 mg/kg; s.c.; 4 hours) concentrations is observed in tumors than in plasma or other nontumor tissues [1]. MSA-2 dimer (THP-1 cells) induces phosphorylation of both TBK1 and IR. MSA-2 dimer (10 μM and 33 μM; macrophages) induces IFN-β[1]. MSA-2 dimer also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes[1]. Animal Model: B16F10 tumor-bearing mice Dosage: 60 mg/kg Administration: P.o.; 50 days Result: Inhibited tumor growth and prolonged overall survival. Animal Model: C57BL6 mice Dosage: 40 mg/kg Administration: S.c.; 25 days Result: Induced complete tumor regression. Animal Model: C57BL6 mice Dosage: 60 mg/kg Administration: P.o.; 4 hours Result: Increased proinflammatory cytokine (IFN-β) level in tumors. Animal Model: C57BL6 mice Dosage: 50 mg/kg Administration: S.c.; 4 hours Result: MSA-2 concentrations were observed in tumors than in plasma or other nontumor tissues. |
| References |
| Molecular Formula | C29H28O8S2 |
|---|---|
| Molecular Weight | 568.66 |