2154342-45-5

2154342-45-5 structure

Name: Pomalidomide-C3-NH2 hydrochloride
Chemical Name: Pomalidomide-C3-NH2 hydrochloride
CAS Number: 2154342-45-5
Molecular Formula: C₁₆H₁₉ClN₄O₄
Molecular Weight: 366.80
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2021-09-30 09:13:10
Modify Date: 2024-01-19 11:46:11
Pomalidomide-C3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Name	Pomalidomide-C3-NH2 hydrochloride
Synonyms	MFCD31729296

Description	Pomalidomide-C3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Molecular Formula	C₁₆H₁₉ClN₄O₄
Molecular Weight	366.80

Hazard Codes	Xi