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1656261-09-4

1656261-09-4 structure
1656261-09-4 structure
  • Name: SCO-267
  • Chemical Name: SCO-267
  • CAS Number: 1656261-09-4
  • Molecular Formula: C36H46N4O5
  • Molecular Weight: 614.77
  • Catalog: Signaling Pathways GPCR/G Protein GPR40
  • Create Date: 2021-09-05 21:07:50
  • Modify Date: 2024-01-11 09:57:54
  • SCO-267 is an allosteric GPR40 full agonist. SCO-267 can be used for the research of chronic diseases including diabetes[1].
Name SCO-267
Description SCO-267 is an allosteric GPR40 full agonist. SCO-267 can be used for the research of chronic diseases including diabetes[1].
Related Catalog
Target

GPR40[1]

In Vitro SCO-267 (CHO cells) activates the Gαq, Gαs, and Gα12/13 pathways and β-Arrestin Recruitment. SCO-267 is allosteric with fasiglifam and an endogenous ligand[1].
In Vivo SCO-267 (1 or 10 mg/kg; p.o.) improves insulin sensitivity and exerts sustained glucose-lowering effect[1]. Animal Model: N-STZ rats[1] Dosage: 1 or 10 mg/kg Administration: P.o.; Result: Improved insulin sensitivity and exerted sustained glucose-lowering effect.
References

[1]. Koyama R, et al. Chronic Exposure to SCO-267, an Allosteric GPR40 Full Agonist, Is Effective in Improving Glycemic Control in Rats. Mol Pharmacol. 2021 Apr;99(4):286-293.
Molecular Formula C36H46N4O5
Molecular Weight 614.77

Chemsrc provides CAS#:1656261-09-4 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 1656261-09-4 | Chemsrc address: https://www.chemsrc.com/en/baike/1681455.html

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