Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Thalidomide-NH-C8-NH2
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Thalidomide-NH-C8-NH2
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

1957236-36-0

1957236-36-0 structure

1957236-36-0 structure

Name: Thalidomide-NH-C8-NH2
Chemical Name: Thalidomide-NH-C8-NH2
CAS Number: 1957236-36-0
Molecular Formula: C₂₁H₂₈N₄O₄
Molecular Weight: 400.47
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2021-09-11 15:40:35
Modify Date: 2024-01-16 19:28:46
Thalidomide-NH-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Name	Thalidomide-NH-C8-NH2

Description	Thalidomide-NH-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Molecular Formula	C₂₁H₂₈N₄O₄
Molecular Weight	400.47