1126626-61-6

1126626-61-6 structure

1126626-61-6 structure

Name: Lasofoxifene-d4
Chemical Name: Lasofoxifene-d4
CAS Number: 1126626-61-6
Molecular Formula: C₂₈H₂₇D₄NO₂
Molecular Weight: 417.58
Catalog: Research Areas Endocrinology
Create Date: 2021-10-28 11:40:07
Modify Date: 2024-01-11 10:48:57
Lasofoxifene-d4 is the deuterium labeled Lasofoxifene. Lasofoxifene is a non-steroidal selective estrogen receptor modulator (SERM)[1][2].

Name	Lasofoxifene-d4

Description	Lasofoxifene-d4 is the deuterium labeled Lasofoxifene. Lasofoxifene is a non-steroidal selective estrogen receptor modulator (SERM)[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Andersson A, et al. Selective oestrogen receptor modulators lasofoxifene and bazedoxifene inhibit joint inflammation and osteoporosis in ovariectomised mice with collagen-induced arthritis. Rheumatology (Oxford). 2015 Sep 30. pii: kev355.

Molecular Formula	C₂₈H₂₇D₄NO₂
Molecular Weight	417.58