1356841-72-9

1356841-72-9 structure

Name: Tetrahydrofolic acid-d4
Chemical Name: Tetrahydrofolic acid-d4
CAS Number: 1356841-72-9
Molecular Formula: C₁₉H₁₉D₄N₇O₆
Molecular Weight: 449.45
Catalog: Research Areas Metabolic Disease
Create Date: 2021-10-18 17:07:35
Modify Date: 2024-01-11 17:53:44
Tetrahydrofolic acid-d4 (L-5,6,7,8-Tetrahydrofolic acid-d4) is the deuterium labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1][2].

Name	Tetrahydrofolic acid-d4

Description	Tetrahydrofolic acid-d4 (L-5,6,7,8-Tetrahydrofolic acid-d4) is the deuterium labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1][2].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Clara B García-Calderón, et al. Genotoxicity of Tetrahydrofolic Acid to Hematopoietic Stem and Progenitor Cells. Cell Death Differ. 2018 Nov;25(11):1967-1979.

Molecular Formula	C₁₉H₁₉D₄N₇O₆
Molecular Weight	449.45