1035438-80-2

1035438-80-2 structure
1035438-80-2 structure
  • Name: Risedronic Acid-d4
  • Chemical Name: 1-hydroxy-2-([2,4,5,6-2H4]-pyridin-3-yl)ethylidene-1,1-bisphosphonic acid
  • CAS Number: 1035438-80-2
  • Molecular Formula: C7H7D4NO7P2
  • Molecular Weight: 287.13700
  • Catalog: Research Areas Others
  • Create Date: 2017-10-05 14:48:02
  • Modify Date: 2024-01-08 15:25:33
  • Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption[1][2].

Name 1-hydroxy-2-([2,4,5,6-2H4]-pyridin-3-yl)ethylidene-1,1-bisphosphonic acid
Synonyms risedronic acid-d4
Risedronic acid-d4
Description Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Giljevic Z, et al. Treatment of osteoporosis by risedronate-- speed, efficacy and safety. Reumatizam. 2006;53(2):66-71.

[3]. Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31.

Molecular Formula C7H7D4NO7P2
Molecular Weight 287.13700
Exact Mass 287.02600
PSA 167.80000