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484-76-4

484-76-4 structure
484-76-4 structure
  • Name: Okanin
  • Chemical Name: okanin
  • CAS Number: 484-76-4
  • Molecular Formula: C15H12O6
  • Molecular Weight: 288.25
  • Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
  • Create Date: 2017-01-21 01:43:43
  • Modify Date: 2024-01-14 12:23:10
  • Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways[1].
Name okanin
Synonyms 3,4,2',3',4'-Pentahydroxy-trans-chalkon
Okanin,2',3,3',4,4'-Pentahydroxychalcone
2',3,3',4,4'-Pentahydroxychalcone
OKANIN
(E)-3-(3,4-Dihydroxyphenyl)-1-(2,3,4-trihydroxyphenyl)-2-propen-1-one
2',3',4',3,4,-PENTAHYDROXYCHALCONE
2'.3'.4'.3.4-Pentahydroxy-chalkon
3,4,2',3',4'-pentahydroxy-trans-chalcone
Description Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways[1].
Related Catalog
Target

TLR4

p65

In Vitro Okanin significantly inhibits LPS-induced TLR4 expression in BV-2 cells. Okanin inhibits the translocation of the NF-κB p65 subunit from the cytosol to the nucleus. Okanin significantly suppresses LPS-induced iNOS expression and also inhibites IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells[1].
References

[1]. Hou Y, et al. Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. Sci Rep. 2017 Apr 3;7:45705.
Density 1.584g/cm3
Boiling Point 638ºC at 760mmHg
Molecular Formula C15H12O6
Molecular Weight 288.25
Flash Point 353.7ºC
Exact Mass 288.06300
PSA 118.22000
LogP 2.11070
Vapour Pressure 7.12E-17mmHg at 25°C
Index of Refraction 1.782
Storage condition -20 °C
528-21-2 structure

528-21-2

139-85-5 structure

139-85-5

~%

484-76-4 structure

484-76-4

Literature: Kurth Journal of the American Chemical Society, 1939 , vol. 61, p. 861
56147-46-7 structure

56147-46-7

~%

484-76-4 structure

484-76-4

Literature: Russell; Todd Journal of the Chemical Society, 1934 , p. 1506
54917-85-0 structure

54917-85-0

~%

484-76-4 structure

484-76-4

Literature: Russell; Todd Journal of the Chemical Society, 1934 , p. 1506

Chemsrc provides CAS#:484-76-4 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 484-76-4 | Chemsrc address: https://www.chemsrc.com/en/baike/168465.html

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