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1452459-52-7

1452459-52-7 structure
1452459-52-7 structure
  • Name: FPI-1523 sodium
  • Chemical Name: FPI-1523 sodium
  • CAS Number: 1452459-52-7
  • Molecular Formula: C9H13N4NaO7S
  • Molecular Weight: 344.28
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2022-03-24 10:25:17
  • Modify Date: 2024-01-12 15:12:34
  • FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity[1].

Name FPI-1523 sodium
Description FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity[1].
Related Catalog
Target

β-lactamase[1]

In Vitro FPI-1523 sodium inhibits K12 E. coli K12 and PBP2, with MIC and IC50 of 4 μg/mL and 0.4 μg/mL, respectively[1]. FPI-1523 sodium inhibit E. coli BW25113 pGDP-2 transformants either with an empty vector or expressing different β-lactamases, with low MICs (1-2 μM)[1].
References

[1]. King AM, et, al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11(4):864-8.

Molecular Formula C9H13N4NaO7S
Molecular Weight 344.28