2580935-57-3
2580935-57-3 structure
- Name: PTPN22-IN-1
- Chemical Name: PTPN22-IN-1
- CAS Number: 2580935-57-3
- Molecular Formula: C26H21N3O5
- Molecular Weight: 455.46
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2021-12-20 10:10:14
- Modify Date: 2024-01-02 18:43:19
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PTPN22-IN-1 is a potent PTPN22 inhibitor (IC50=1.4 µM; Ki=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses[1]. From WO2021007491A1 compound L-1.
| Name | PTPN22-IN-1 |
|---|
| Description | PTPN22-IN-1 is a potent PTPN22 inhibitor (IC50=1.4 µM; Ki=0.50 µM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses[1]. From WO2021007491A1 compound L-1. |
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| Related Catalog | |
| In Vitro | PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects[1]. Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 µM h and Cmax of 1.1 1 µM (Fig. 9d), which is more than twice of its Ki value[1]. |
| In Vivo | PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects[1]. Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 µM h and Cmax of 1.1 1 µM (Fig. 9d), which is more than twice of its Ki value[1]. |
| References |
[1]. Elizabeth Jaffee, et al. Targeting ptpn22 in cancer therapy. WO2021007491A1. |
| Molecular Formula | C26H21N3O5 |
|---|---|
| Molecular Weight | 455.46 |