1227961-59-2

1227961-59-2 structure

Name: Seco-DUBA
Chemical Name: Seco-DUBA
CAS Number: 1227961-59-2
Molecular Formula: C₂₉H₂₃ClN₄O₄
Molecular Weight: 526.97
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2022-03-14 16:12:35
Modify Date: 2024-01-06 20:26:06
Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	Seco-DUBA

Description	Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Research Areas >> Inflammation/Immunology
In Vitro	Seco-DUBA (SK-BR-3 cells; 0.0001 pM~0.01 nM; 144 hours) dose-dependent reduces cell viability and shows equally potent and efficacious as DUBA[1]. Seco-DUBA causes SK-BR-3 (IC50=0.09), SK-OV-3 (IC50=0.43), and SW620 (IC50=0.09) cells to exhibit highly sensitive[1]. Cell Cytotoxicity Assay[1] Cell Line: SK-BR-3 cells Concentration: 0.0001 pM~0.01 nM Incubation Time: 144 hours Result: Dose-dependent reduced cell viability.
In Vivo	Seco-DUBA (89 μg/kg; i.v.) is likely converted to DUBA almost instantaneously[1]. Animal Model: Wistar rats[1] Dosage: 89 μg/kg (Pharmacokinetic Analysis) Administration: I.v. Result: Likely converted to DUBA almost instantaneously.
References	[1]. Elgersma RC, et al. Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985. Mol Pharm. 2015;12(6):1813-1835. [2]. Platform Technologies in Drug Discovery and Validation

Molecular Formula	C₂₉H₂₃ClN₄O₄
Molecular Weight	526.97