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2227482-41-7

2227482-41-7 structure
2227482-41-7 structure
  • Name: ELOVL1-IN-1
  • Chemical Name: ELOVL1-IN-1
  • CAS Number: 2227482-41-7
  • Molecular Formula: C18H14F2N4O
  • Molecular Weight: 340.33
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2022-03-08 18:13:05
  • Modify Date: 2024-01-11 16:16:57
  • ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD)[1].

Name ELOVL1-IN-1
Description ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD)[1].
Related Catalog
Target

ELOVL1[1]

In Vitro ELOVL1-IN-1 (compound 87) (1 nM-10 μM; 48 h) reduces the the level of VLCFA, lysophosphatidylcholine (LPC) in adrenoleukodystrophy (ALD) patient fibroblasts and healthy human fibroblasts, ALD patient B‐lymphocytes, and human microglia[1].
In Vivo ELOVL1-IN-1 (compound 87) reduces of a VLCFA level, specifically C26:0 LPC level in blood of ABCD1 knockout (KO) mice (0.5-64 mg/kg; p.o. once daily for 28 days), wild‐type (WT) rats (30-300 mg/kg; p.o. once daily for 7 days), and cynomolgous monkeys (30 mg/kg; p.o. once daily for 7 days)[1].
References

[1]. Charifson PS, et, al. 1,3-substitued pyrazole compounds useful for reduction of very long chain fatty acic levels. WO2018107056A1.

Molecular Formula C18H14F2N4O
Molecular Weight 340.33