Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GCA-186
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Gca-186
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

149950-61-8

149950-61-8 structure

149950-61-8 structure

Name: Gca-186
Chemical Name: GCA-186
CAS Number: 149950-61-8
Molecular Formula: C₁₉H₂₆N₂O₃
Molecular Weight: 330.42
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-03-08 07:20:07
Modify Date: 2024-01-13 19:33:01
GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].

Name	GCA-186

Description	GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
In Vitro	GCA-186 shows antiviral activity (EC50=0.6 nM) and cytotoxicity against HIV-1 in MT-4 cells (CC50=43 μM)[2].
References	[1]. El-Brollosy NR, et al. Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186. Arch Pharm (Weinheim). 2008;341(1):9-19. [2]. Hopkins AL, et al. Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J Med Chem. 1999;42(22):4500-4505.

Molecular Formula	C₁₉H₂₆N₂O₃
Molecular Weight	330.42