1261171-52-1
1261171-52-1 structure
- Name: mGluR5 modulator 1
- Chemical Name: mGluR5 modulator 1
- CAS Number: 1261171-52-1
- Molecular Formula: C18H19ClFN3O2
- Molecular Weight: 363.81
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2022-03-12 09:52:52
- Modify Date: 2024-01-14 20:47:21
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mGluR5 modulator 1 is a mGluR5 positive allosteric modulator. mGluR5 modulator 1 can be used for the research of the schizophrenia and cognitive impairments[1].
| Name | mGluR5 modulator 1 |
|---|
| Description | mGluR5 modulator 1 is a mGluR5 positive allosteric modulator. mGluR5 modulator 1 can be used for the research of the schizophrenia and cognitive impairments[1]. |
|---|---|
| Related Catalog | |
| Target |
mGluR5[1] |
| In Vitro | mGluR5 modulator 1 (compound 2c; 0.1-0.00001 nM) potentiates the L-glutamate and DHPG responses to the same maximum response as the orthosteric agonists alone in the Ca2+ mobilization and IP1 accumulation assays[1]. mGluR5 modulator 1 (0.1-0.00001 nM) potentiates the L-glutamate and DHPG responses above the orthosteric agonist maximal response in the ERK1/2 phosphorylation assay[1]. mGluR5 modulator 1 induces mGlu5 internalization in the absence of add orthosteric agonist or antagonist[1]. mGluR5 modulator 1 potentiates the responses induced by both orthosteric agonists (L-glutamate or DHPG) in Ca2+ mobilization (pKB=5.4 and 5.3, respecyively), inositol monophosphate accumulation, and ERK1/2 phosphorylation signaling (pKB=5.88 and 5.4, respecyively) assays in HEK293A-mGlu5-low cells[1]. mGluR5 modulator 1 enhances the effect of DHPG in cortical neurons with pEC50 values of 6.32 and 6.33 in Ca2+ mobilization and inositol monophosphate (IP1) accumulation assays[1]. |
| References |
| Molecular Formula | C18H19ClFN3O2 |
|---|---|
| Molecular Weight | 363.81 |