183896-00-6

183896-00-6 structure

Name: Biotin-PEG3-C3-NH2
Chemical Name: N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
CAS Number: 183896-00-6
Molecular Formula: C₂₀H₃₈N₄O₅S
Molecular Weight: 446.60
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2022-03-16 16:41:12
Modify Date: 2024-01-31 19:51:24
Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1].

Name	N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
Synonyms	MFCD28053681

Description	Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTAC linkers exert function for connecting the two different ligands that make up PROTACs, the two ligands are E3 ubiquitin ligase and the target protein, respectively[1]. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. PROTAC can significantly attenuate tumor progression in tumor xenografts[1]. Biotin-PEG3-C3-NH2 (compound 11) (0-2 mM; 3 h) combinded with protein G (compound 6) displays fluorescence under streptavidin probes, Biotin-PEG3-C3-NH2 is a powerful tool for the high-throughput analysis of protein-small molecule interaction and profiling enzyme activities in a microarrays constructed by surface derivatization method[3].