180268-82-0

180268-82-0 structure

Name: L-Phenylalanine-13C6
Chemical Name: L-Phenylalanine-¹³C6
CAS Number: 180268-82-0
Molecular Formula: C₃₁₃C₆H₁₁NO₂
Molecular Weight: 171.15
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2022-03-28 01:34:01
Modify Date: 2024-01-11 18:46:58
L-Phenylalanine-13C6 ((S)-2-Amino-3-phenylpropionic acid-13C6) is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

Name	L-Phenylalanine-¹³C6
Synonyms	L-(1,2,3,4,5,6-13C6)Phenylalanine L-PHENYL-13C6-ALANINE L-Phenylalanine-1,2,3,4,5,6-13C6 (2S)-2-Amino-3-phenylpropanoic Acid-13C6 MFCD00144663

Description	L-Phenylalanine-13C6 ((S)-2-Amino-3-phenylpropionic acid-13C6) is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.