927878-49-7

927878-49-7 structure

Name: TFC 007
Chemical Name: TFC 007
CAS Number: 927878-49-7
Molecular Formula: C₂₇H₂₉N₅O₄
Molecular Weight: 487.55
Catalog: Signaling Pathways Immunology/Inflammation PGE synthase
Create Date: 2022-03-29 18:31:07
Modify Date: 2024-01-19 20:23:55
TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC50 value of 83 nM). TFC-007 can be used for composing H-PGDS degradation inducer PROTAC(H-PGDS)-1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon)[1].

Name	TFC 007
Synonyms	5-Pyrimidinecarboxamide, N-[4-[4-(4-morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy- N-{4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl}-2-phenoxy-5-pyrimidinecarboxamide N-[4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide

Description	TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC50 value of 83 nM). TFC-007 can be used for composing H-PGDS degradation inducer PROTAC(H-PGDS)-1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PGE synthase
References	[1]. Hidetomo Yokoo, et al. Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer. ACS Med Chem Lett. 2021 Jan 14;12(2):236-241.