1631164-25-4

1631164-25-4 structure

Name: BAY 1214784
Chemical Name: BAY 1214784
CAS Number: 1631164-25-4
Molecular Formula: C₂₉H₂₆ClF₄N₃O₅S₂
Molecular Weight: 672.11
Create Date: 2022-05-17 10:24:17
Modify Date: 2024-01-03 02:29:42
BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids[1].

Name	BAY 1214784

Description	BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Cancer
References	[1]. Panknin O, et al. Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women. J Med Chem. 2020;63(20):11854-11881

Molecular Formula	C₂₉H₂₆ClF₄N₃O₅S₂
Molecular Weight	672.11