Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HIF-1α-IN-2
Price:
Purity: 98.45%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: HIF-1α-IN-2
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2762315-06-8

2762315-06-8 structure

2762315-06-8 structure

Name: HIF-1α-IN-2
Chemical Name: HIF-1α-IN-2
CAS Number: 2762315-06-8
Molecular Formula: C₂₁H₁₉N₃OS
Molecular Weight: 361.46
Create Date: 2022-05-09 11:45:44
Modify Date: 2024-01-03 14:46:05
HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation[1].

Name	HIF-1α-IN-2

Description	HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 28 nM (HIF-1α) in MDA-MB-231, 15 nM (HIF-1α) in MiaPaCa-2[1]
In Vitro	HIF-1α-IN-2 (compound 7f) (5 μM; 72h) suppresses the viability of MDA-MB-231 and MiaPaCa-2 cells with IC50s of 28 nM and 15 nM, respectively[1]. HIF-1α-IN-2 (0-1 μM; 72h) suppresses the expression of HIF-1α and VEGF with dose-dependent effect[1]. HIF-1α-IN-2 (0.25, 0.5, and 1 µM; 16-24h) can significantly inhibit the migration of MDA-MD-231 cells by 56% (0.25 µM), 83% (0.5 µM), and 85% (1 µM), respectively, and also noted in MiaPaCa-2 cells, which demonstrates the unique anti-migration effect of HIF-1α-IN-2[1]. HIF-1α-IN-2 (0-1 μM; 72h) suppresses HIF-1α mRNA levels in MDA-MB-231 cells under hypoxia[1]. Cell Viability Assay Cell Line: MDA-MB-231 cells, MiaPaCa-2 cells[1] Concentration: 5 μM Incubation Time: 72 hours Result: Suppressed the viability of these two cell lines with IC50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively. Cell Viability Assay Cell Line: MDA-MB-231 cells, MiaPaCa-2 cells[1] Concentration: 5 μM Incubation Time: 72 hours Result: Suppressed the viability of these two cell lines with IC50 of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively.
References	[1]. Wu YC, et al. Synthesis and evaluation of biarylquinoline derivatives as novel HIF-1α inhibitors. Bioorg Chem. 2022;121:105681.

Molecular Formula	C₂₁H₁₉N₃OS
Molecular Weight	361.46