2669785-76-4

2669785-76-4 structure

Name: JPS014
Chemical Name: JPS014
CAS Number: 2669785-76-4
Molecular Formula: C₄₆H₅₉N₇O₇S
Molecular Weight: 854.07
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-05-24 11:32:20
Modify Date: 2024-04-05 13:29:34
JPS014 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 degrades class I histone deacetylase (HDAC). JPS014 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Name	JPS014

Description	JPS014 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 degrades class I histone deacetylase (HDAC). JPS014 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65(7):5642-5659.

Molecular Formula	C₄₆H₅₉N₇O₇S
Molecular Weight	854.07