2748267-73-2

2748267-73-2 structure

Name: Etoricoxib-13C,d3
Chemical Name: Etoricoxib-13C,d3
CAS Number: 2748267-73-2
Molecular Formula: C₁₇₁₃CH₁₂D₃ClN₂O₂S
Molecular Weight: 362.85
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-06-30 19:23:42
Modify Date: 2024-01-08 22:41:26
Etoricoxib-13C,d3 is the 13C- and deuterium labeled. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

Name	Etoricoxib-13C,d3

Description	Etoricoxib-13C,d3 is the 13C- and deuterium labeled. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[66].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Riendeau D, et al.Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharmacol Exp Ther. 2001 Feb;296(2):558-66. [3]. Kunak CS, et al. The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats. Oxid Med Cell Longev. 2015;2015:598162. [4]. Tanwar L, et al. Anti-proliferative and apoptotic effects of etoricoxib, a selective COX-2 inhibitor, on 1,2-dimethylhydrazine dihydrochloride-induced colon carcinogenesis. Asian Pac J Cancer Prev. 2010;11(5):1329-33.

Molecular Formula	C₁₇₁₃CH₁₂D₃ClN₂O₂S
Molecular Weight	362.85