2744683-81-4

2744683-81-4 structure

Name: Famotidine-13C,d3
Chemical Name: Famotidine-13C,d3
CAS Number: 2744683-81-4
Molecular Formula: C₇₁₃CH₁₂D₃N₇O₂S₃
Molecular Weight: 341.46
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2022-07-12 13:50:15
Modify Date: 2024-01-09 19:05:30
Famotidine-13C,d3 is the 13C- and deuterium labeled. Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

Name	Famotidine-13C,d3

Description	Famotidine-13C,d3 is the 13C- and deuterium labeled. Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[63].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Inan, A., et al., Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo), 2009. 64(6): p. 567-70. [3]. Miyata, K., et al., Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol, 1991. 55(2): p. 211-22.

Molecular Formula	C₇₁₃CH₁₂D₃N₇O₂S₃
Molecular Weight	341.46