250608-66-3

250608-66-3 structure

250608-66-3 structure

Name: Sulindac sulfide-d3
Chemical Name: Sulindac sulfide-d3
CAS Number: 250608-66-3
Molecular Formula: C₂₀H₁₄D₃FO₂S
Molecular Weight: 343.43
Catalog: Research Areas Neurological Disease
Create Date: 2022-07-31 17:45:38
Modify Date: 2024-04-06 12:17:24
Sulindac sulfide-d3 is deuterium labeled Sulindac sulfide. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.

Name	Sulindac sulfide-d3

Description	Sulindac sulfide-d3 is deuterium labeled Sulindac sulfide. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.
Related Catalog	Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Takahashi Y, et al. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J Biol Chem. 2003 May 16;278(20):18664-70.

Molecular Formula	C₂₀H₁₄D₃FO₂S
Molecular Weight	343.43