32004-67-4

32004-67-4 structure

Name: Sulindac Sulfide
Chemical Name: Sulindac sulfide
CAS Number: 32004-67-4
Molecular Formula: C₂₀H₁₇FO₂S
Molecular Weight: 340.411
Catalog: Research Areas Neurological Disease
Create Date: 2018-10-03 22:10:33
Modify Date: 2024-01-05 18:56:15
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer’s disease[1].

Name	Sulindac sulfide
Synonyms	MFCD00869764 {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)- EINECS 250-892-2 SULINDAC SULFIDE 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)inden-3-ylacetic acid ; [Sulindac Sulfide ] 5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid

Description	(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). (E/Z)-Sulindac sulfide selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer’s disease[1].
Related Catalog	Research Areas >> Neurological Disease
Target	γ-secretase, Amyloid-β[1]
References	[1]. Richter L, et al. Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602.

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H317-H334-H361
Precautionary Statements	P261-P280-P342 + P311
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R42/43;R63
RIDADR	NONH for all modes of transport
WGK Germany	3