1215115-03-9
1215115-03-9 structure
- Name: HuR inhibitor KH-3
- Chemical Name: HuR inhibitor KH-3
- CAS Number: 1215115-03-9
- Molecular Formula: C21H22N2O4S2
- Molecular Weight: 430.537
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2022-07-01 16:38:02
- Modify Date: 2024-01-06 18:27:22
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HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model.
| Name | HuR inhibitor KH-3 |
|---|
| Description | HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model. |
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| References | 1. Xiaoqing Wu, et al. Commun Biol. 2020 Apr 24;3(1):193. 2. Simeng Liu, et al. Clin Sci (Lond). 2020 Jun 26;134(12):1433-1448. |
| Molecular Formula | C21H22N2O4S2 |
|---|---|
| Molecular Weight | 430.537 |