2762552-74-7

2762552-74-7 structure

Name: STING PROTAC SP23
Chemical Name: STING PROTAC SP23
CAS Number: 2762552-74-7
Molecular Formula: C₃₄H₃₃N₇O₁₀
Molecular Weight: 699.677
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2022-07-11 16:14:23
Modify Date: 2024-04-06 18:05:36
SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway.

Name	STING PROTAC SP23

Description	SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway.
References	1. Jin Liu, et al. J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.1c01948.

Molecular Formula	C₃₄H₃₃N₇O₁₀
Molecular Weight	699.677