16752-89-9
16752-89-9 structure
- Name: TGP-377/421
- Chemical Name: TGP-377/421
- CAS Number: 16752-89-9
- Molecular Formula: C20H16N6
- Molecular Weight: 340.39
- Catalog: Signaling Pathways Epigenetics MicroRNA
- Create Date: 2022-07-01 17:38:01
- Modify Date: 2024-10-01 13:41:55
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TGP-377/421 (Targapre-miR-377/421) is a smalll molecule targets pre-miR-377 and inhibits its processing, binds to miR-377's Dicer processing site with Kd of 29 uM.TGP-377/421 inhibits the cellular biogenesis of miR-377 in HUVECs, reduced mature miR-377 levels in a dose-dependent fashion with IC50 of 5 uM, also inhibits miR-421.
| Name | TGP-377/421 |
|---|
| Description | TGP-377/421 (Targapre-miR-377/421) is a smalll molecule targets pre-miR-377 and inhibits its processing, binds to miR-377's Dicer processing site with Kd of 29 uM.TGP-377/421 inhibits the cellular biogenesis of miR-377 in HUVECs, reduced mature miR-377 levels in a dose-dependent fashion with IC50 of 5 uM, also inhibits miR-421. |
|---|---|
| References | 1. Hafeez S Haniff, et al. Nat Chem. 2020 Oct;12(10):952-961. |
| Molecular Formula | C20H16N6 |
|---|---|
| Molecular Weight | 340.39 |