1808948-28-8

1808948-28-8 structure

Name: (2S,3R)-LP99
Chemical Name: (2S,3R)-LP99
CAS Number: 1808948-28-8
Molecular Formula: C₂₆H₃₀ClN₃O₄S
Molecular Weight: 516.05
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2022-07-11 10:44:19
Modify Date: 2024-01-12 11:37:43
(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].

Name	(2S,3R)-LP99

Description	(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD7 BRD9:99 nM (Kd)
In Vitro	(2S,3R)-LP99 (compound 60) (0-100 µM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells[1].
References	[1]. Clark PG, et al. LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21.

Molecular Formula	C₂₆H₃₀ClN₃O₄S
Molecular Weight	516.05